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"The finding that GR sensitizes PTEN mutant cells to death is absolutely new; it was the opposite of what you would expect," Dr. Papa said. The long-term research involved 32 hospitals and medical centres in ten countries spanning from the UK to Germany, France, Italy, Norway, Poland, Switzerland, Canada, Australia and America. They avoid side effects of whole breast radiotherapy. The study, published in the BMJ, looks at the therapy developed by University College London clinicians which is increasingly accessible throughout the world. What are the symptoms of colon cancer and can it be treated? The treatment takes about 20 to 30 minutes to carry out and eradicates the need for additional hospital visits – taking far less time out of patient's lives and thereby boosting their well-being. The researchers demonstrated using animal models, organoids and proteomic screening, that the loss of PTEN synergises with mutant PI3K gene in forming tumors in mammary glands. A breakthrough breast cancer therapy which requires just one shot of radiotherapy unlike the traditional treatment which takes weeks has been found to be as effective in treating the illness. This document is subject to copyright. What are the symptoms of male breast cancer and how common is it? We do not guarantee individual replies due to extremely high volume of correspondence. Click here to sign in with The latest breaking news, comment and features from The Independent. The content is provided for information purposes only. In contrast, PI3K is an enzyme that promotes cell growth and sustains proliferation in cancer when mutated. "These patients could benefit from our findings," Dr. Papa said. The existing Open Comments threads will continue to exist for those who do not subscribe to Independent Premium. The study, published in Molecular Cell and led by Dr. Antonella Papa, identified potential new treatments for patients who lacked PTEN, a gene that suppresses tumors, and/or have mutations in the cancer gene PI3K. Findings by Monash Biomedicine Discovery Institute (BDI) researchers have pointed to a new combination of treatments that may help breast cancer patients with certain gene mutations. Are you sure you want to delete this comment? You can also choose to be emailed when someone replies to your comment. PTEN gives instructions for making an enzyme found in most tissues in the body and functions by stopping cells from growing and dividing too rapidly or too uncontrollably. Lifestyle. Professor Jayant Vaidya, who was the study’s lead author, said: “With TARGIT-IORT, women can have their surgery and radiation treatment for breast cancer all at the same time. What are the symptoms of colon cancer and how is it treated? part may be reproduced without the written permission. Mia Rosenblatt, of Breast Cancer Now, said: “This encouraging research provides further evidence that radiotherapy delivered at the same time as breast-conserving surgery for some women with early breast cancer offers similar outcomes to traditional radiotherapy. Coronavirus: What is social shielding and who needs to do it? The most insightful comments on all subjects will be published daily in dedicated articles. Ms Rosenblatt added: "Anyone with questions or concerns about their current breast cancer treatment can call our free helpline on 0808 800 6000. I've been waiting four months to find out, Anderson Cooper remembers late mother a year after her death, Wearable patch may provide new treatment option for skin cancer, Hospitals to ‘maximise’ use of private sector to clear cancer backlog, Chemo buses and at-home treatment increased to help cancer sufferers, John Cleese reveals health scare after having cancerous tumour removed, Millions of cancer patients waiting for screenings due to Covid delays, Blood test could predict cancer patients’ response to treatment, Bayer reaches deal to settle 85,000 cancer lawsuits over Roundup. MPs are back. or, by Monash University. In addition, 10 per cent of breast cancer patients have combined genetic alterations in these two genes. Substantially fewer women also died from causes other than breast cancer with the new treatment. The information you enter will appear in your e-mail message and is not retained by Medical Xpress in any form. Start your Independent Premium subscription today. Lockdown has brought small comfort in grieving for my late husband, Thousands with breast cancer 'fearing they could die more quickly', Climate change 'undermining progress in fight against cancer', We need government reassurance far beyond the easing of the lockdown. Some 2,298 women who were older than 45 with breast cancer and a tumour of up to 3.5cm in size were randomly selected to either have TARGIT-IORT or external beam radiotherapy for the study. Our journalists will try to respond by joining the threads when they can to create a true meeting of independent Premium. Staying at a healthy weight, staying active throughout life, following a healthy eating pattern, and avoiding or limiting alcohol may greatly reduce a person's lifetime risk of developing or dying from cancer. “We know that the innovative Intrabeam treatment is already available in some areas, and can reduce the need for multiple hospital visits and lessen the side-effects experienced. By using our site, you acknowledge that you have read and understand our Privacy Policy Around 55,000 women and 370 men are diagnosed with breast cancer, which is the most prevalent type of cancer in the UK, each year – with around 11,500 women and 80 men dying from the disease in Britain every year. Your feedback will go directly to Science X editors. The researchers found that combining a treatment called dexamethasone (an anti-inflammatory medication currently available), which activates GR, with an AKT inhibitor, better suppressed growth of PTEN/PI3K mutant cancer cells than treatment with a single compound. Professor Jeffrey Tobias, another author, noted the new therapy does away with patients having to go to the radiotherapy centre every day. Want an ad-free experience?Subscribe to Independent Premium. This can make a huge difference at an already challenging time.". Karsten Thielker, Pulitzer-winning AP photographer, dies, Eitan Haber, trusted aide to Yitzhak Rabin, dies at 80, Guitar rock legend Eddie Van Halen dies of cancer at 65, Jimmy Kimmel, Billy Idol react to death of Eddie Van Halen, Guitar rock god Eddie Van Halen dies of cancer at 65, Bob Gibson, Hall of Fame ace for Cardinals, dies at 84. “This reduces the amount of time spent in hospital and enables women to recover more quickly, meaning they can get back to their lives more quickly. Other cancer therapies, such as chemotherapy and radiation, have been linked to a decline in cognitive function. Want to bookmark your favourite articles and stories to read or reference later? and Terms of Use. Your opinions are important to us. She said it is crucial all women have clear information about the "benefits and risks" of the different ways of delivering radiotherapy to enable them to make an "informed choice". In a surprising finding, the team also discovered that loss of PTEN function increased levels of the glucocorticoid receptor (GR) and made the tumor cells more prone to death. Please continue to respect all commenters and create constructive debates. Neither your address nor the recipient's address will be used for any other purpose. You can unsubscribe at any time and we'll never share your details to third parties. Create a commenting name to join the debate, There are no Independent Premium comments yet - be the first to add your thoughts, There are no comments yet - be the first to add your thoughts. The study, published in the BMJ, looks at the therapy developed by University College London clinicians which is increasingly accessible throughout the world, Breast cancer breakthrough as treatment requires one radiotherapy shot, Thousands with breast cancer ‘fearing they could die more quickly’, Breast cancer screening for women in their 40s ‘could save lives’, You may not agree with our views, or other users’, but please respond to them respectfully, Swearing, personal abuse, racism, sexism, homophobia and other discriminatory or inciteful language is not acceptable, Do not impersonate other users or reveal private information about third parties, We reserve the right to delete inappropriate posts and ban offending users without notification. Apart from any fair dealing for the purpose of private study or research, no Researchers found with the breakthrough new single-dose breast cancer therapy, eight out of every ten patients did not require any further post-operative radiotherapy treatments. Phys.org internet news portal provides the latest news on science, Tech Xplore covers the latest engineering, electronics and technology advances, Science X Network offers the most comprehensive sci-tech news coverage on the web. The American Cancer Society has updated its guideline on diet and physical activity for cancer prevention. Do parents need to be concerned about Johnson & Johnson talc? So how did they do at holding the government to account? This site uses cookies to assist with navigation, analyse your use of our services, and provide content from third parties. Conventional external beam radiotherapy (EBRT) involves a daily treatment session to the whole breast over a period which spans from three to six weeks – involving anywhere from 15 to 30 trips to the hospital in total. How to check your breasts for cancer symptoms, Timothy Ray Brown, 1st person cured of HIV, dies of cancer, Poor areas have 20,000 more cancer cases a year than rich ones, New measurements show moon has hazardous radiation levels, Moon has hazardous radiation levels, scientists warn, First man cured of HIV infection now has terminal cancer, Fundraising goes on as Leah Still at 5 years cancer free, MIT professor wins top AI award for cancer, drug research, Breast cancer survivor detects cancer using AI, Gale Sayers, Bears Hall of Fame running back, dies at 77, I had ovarian cancer. He said: “With TARGIT-IORT, a large proportion of patients with breast cancer will never need to make the repeated daily visits to the radiotherapy centre. Independent Premium Comments can be posted by members of our membership scheme, Independent Premium. Our nurses are just at the end of the phone". Subscribe now. Due to the sheer scale of this comment community, we are not able to give each post the same level of attention, but we have preserved this area in the interests of open debate. You can find our Community Guidelines in full here. A breakthrough breast cancer therapy which requires just one shot of radiotherapy unlike the traditional treatment which takes weeks has … Gene therapy is a form of treating disease by editing or altering the genes within the cells of the body. Importantly, TARGIT-IORT reduces the burden on overstretched radiotherapy departments.”. They then found that inhibiting the protein AKT suppressed the growth of PTEN and PI3K mutant mammary organoids. Tech Xplore. Professor Michael Baum, one of the study’s authors, said: “These results are the highest level of evidence proving not only the effectiveness of TARGIT-IORT but confirming that it avoids deaths from other causes.

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